A major British clinical trial has found hydroxychloroquine has “no benefit” for patients hospitalized with COVID-19, scientists said Friday, in the first large-scale study to provide results for a drug at the center of political and scientific controversy. Hydroxychloroquine, a decades-old malaria and rheumatoid arthritis drug, has been touted as a possible treatment for the new coronavirus by high profile figures, including US President Donald Trump, and has been included in several randomized clinical trials.The University of Oxford’s Recovery trial, the biggest of these so far to come forward with findings, said that it would now stop recruiting patients to be given hydroxychloroquine “with immediate effect”. Researchers said 1,542 patients were randomly assigned to hydroxychloroquine and compared with 3,132 patients given standard hospital care alone.They found “no significant difference” in mortality after 28 days between the two groups, and no evidence that treatment with the drug shortens the amount of time spent in hospital.”This is a really important result, at last providing unequivocal evidence that hydroxychloroquine is of no value in treatment of patients hospitalized with COVID-19,” said Peter Openshaw, a professor at Imperial College London, in reaction to the results.He added that the drug was “quite toxic” so halting the trials would be of benefit to patients. Hydroxychloroquine has been in use for years but it has a number of potentially serious side effects, including heart arrhythmia.Researchers from the Recovery trial said they would share their data with the World Health Organization (WHO), which on Wednesday restarted its own trials of hydroxychloroquine.They were temporarily halted last month because of a now-retracted observational study in The Lancet medical journal that had suggested hydroxychloroquine and chloroquine, a related compound, were ineffective against COVID-19 and even increased the risk of death.Authors of The Lancet research said on Thursday that they could no longer vouch for the integrity of its underlying data, in the face of serious concerns raised by fellow scientists over a lack of clarity about the countries and hospitals that contributed patient information. The scandal cast a shadow over The Lancet and another top medical journal, but it did nothing to clear up the increasingly politicized question of whether or not hydroxychloroquine works as a treatment for COVID-19.Openshaw said the Recovery trial should be credited with continuing the research until they could reach a definitive conclusion on hydroxychloroquine.”Everyone regrets that it doesn’t work, but knowing that allows us to focus on finding drugs that actually help recovery from COVID-19,” he added.Oxford professor Peter Horby, the lead investigator on the Recovery Trial, said there was probably a “very large number” of people around the world taking hydroxychloroquine for COVID-19, with countries including the US, China and Brazil authorizing it.A separate clinical trial on Wednesday in the US and Canada found that taking hydroxychloroquine shortly after being exposed to COVID-19 does not work to prevent infection significantly better than a placebo.Topics : “Our conclusion is that this treatment does not reduce the risk of dying from COVID among hospital patients and that clearly has a significant importance for the way patients are treated, not only in the UK, but all around the world,” said Martin Landray, an Oxford professor of medicine and epidemiology who co-leads the study.The randomized clinical trial—considered the gold standard for clinical investigation—has recruited a total of 11,000 patients from 175 hospitals in the UK to test a range of potential treatments.Other drugs continuing to be tested include: the combination of HIV antivirals Lopinavir and Ritonavir; a low dose of the steroid Dexamethasone, typically used to reduce inflammation; antibiotic Azithromycin; and the anti inflammatory drug Tocilizumab.Researchers are also testing convalescent plasma from the blood of people who have recovered from COVID-19, which contains antibodies to fight the virus.
Advertisement Metro Sport ReporterSunday 4 Aug 2019 11:41 pmShare this article via facebookShare this article via twitterShare this article via messengerShare this with Share this article via emailShare this article via flipboardCopy link2kShares Manchester City manager Pep Guardiola has rated his rivals’ title chances (Picture: Getty)Pep Guardiola insists Manchester United, Arsenal, Tottenham and Chelsea can all rival Manchester City and Liverpool for the Premier League title this season.Man City won a second successive Premier League last term, edging out Liverpool by one point in one of the tightest and most memorable title races in history.City and Liverpool pulled away from the likes of Chelsea, Tottenham, Arsenal and Manchester United but Guardiola believes his side will face more competition to win the title this season.Speaking after Manchester City’s Community Shield victory over Liverpool, Guardiola said: ‘I don’t know if it’ll be like last season with two real contenders to win the Premier League.AdvertisementAdvertisementADVERTISEMENTMore: FootballRio Ferdinand urges Ole Gunnar Solskjaer to drop Manchester United starChelsea defender Fikayo Tomori reveals why he made U-turn over transfer deadline day moveMikel Arteta rates Thomas Partey’s chances of making his Arsenal debut vs Man City‘I think United, with [Harry] Maguire, and the others have bought – Arsenal as well and Chelsea and Tottenham. So I think there will be many contenders this time.’Asked specifically whether Maguire, who Manchester City were linked with earlier in the summer, was good enough to turn United into title contenders, Guardiola said: ‘Yes. He is an excellent, top-class player.‘We were interested but we could not afford it and United can afford it.‘He made an incredible World Cup, strong in the air, good with the ball and drives with the ball so fast. He has all the qualities to work for United. Congratulations to United for the signing.’ Advertisement Pep Guardiola rates Man Utd, Arsenal, Tottenham and Chelsea’s Premier League title chances Comment Guardiola was speaking after Man City’s Community Shield triumph (Picture: Getty)Manchester City will attempt to win a third straight Premier League title this season and the early signs are promising with Guardiola’s side beating Liverpool on penalties in the Community Shield.On the clash at Wembley, Guardiola added: ‘An incredible final from both sides. No team can dominate for 90 minutes.‘We had real good moments. In the last 15 minutes we were exhausted and they had chances to win the game.‘It was a good test for both teams. It’s nice for the players to realise what they will face this season. At this level the difference is nothing. One penalty, one point.More: FootballBruno Fernandes responds to Man Utd bust-up rumours with Ole Gunnar SolskjaerNew Manchester United signing Facundo Pellistri responds to Edinson Cavani praiseArsenal flop Denis Suarez delivers verdict on Thomas Partey and Lucas Torreira moves‘Manchester United will be back, Arsenal, Tottenham, Chelsea… I don’t know what will happen.’Liverpool manager Jurgen Klopp, meanwhile, said: ‘Wow, it was a really good performance, a powerful one in the second half.‘Both teams had a similar pre-season. I spoke to Kevin de Bruyne after the game and we both said we don’t really know where we are yet.‘The least we deserved was the equaliser, one save decided it and I cannot be disappointed today. The performance was much more important than a win.’MORE: Arsenal fans tell Unai Emery to sell three players after Barcelona defeat
Jose Mourinho explains why Alexis Sanchez flopped at Manchester United after Arsenal transfer Metro Sport ReporterFriday 13 Sep 2019 11:39 amShare this article via facebookShare this article via twitterShare this article via messengerShare this with Share this article via emailShare this article via flipboardCopy link1.2kShares Advertisement Alexis Sanchez failed to live up to expectations after joining Man Utd from Arsenal (Picture: Getty)Jose Mourinho believes Alexis Sanchez’s inherrant sadness meant he was always destined to fail at Manchester United.Much was expected of the Chile international after he arrived at Old Tafford following his acrimonious departure from Arsenal but he failed to produce anywhere near his best form.Both Mourinho and his successor, Ole Gunnar Solskjaer, failed to illicit the sort of performances which marked Sanchez out as one of the Premier League’s most feared attackers.The 30-year-old joined Inter on loan earlier this month and this week claimed that too much chopping and changing was the main reason behind a return of just three goals in 32 Premier League appearances.AdvertisementAdvertisementADVERTISEMENTMore: FootballRio Ferdinand urges Ole Gunnar Solskjaer to drop Manchester United starChelsea defender Fikayo Tomori reveals why he made U-turn over transfer deadline day moveMikel Arteta rates Thomas Partey’s chances of making his Arsenal debut vs Man City Advertisement Comment Alexis Sanchez joined Inter on loan from Man Utd earlier this month (Picture: Getty)Mourinho, however, had a different take, telling the Daily Telegraph: ‘Sanchez… I felt him [to be] not a happy man.‘And I think in every job you have when you are not happy it is not so easy to perform at every level.‘And maybe I am wrong. Maybe it was me who was not capable to get into him and to get the best out of him.‘As a manager sometimes you have the capacity to get the best out of the players and other times you are not successful in that approach.‘But the reality is that I always felt [of Sanchez], ‘a sad man’. So probably in Italy he will recover this. I hope he can. I always wish well to every player.’More: Manchester United FCRio Ferdinand urges Ole Gunnar Solskjaer to drop Manchester United starNew Manchester United signing Facundo Pellistri responds to Edinson Cavani praiseEx-Man Utd coach blasts Ed Woodward for two key transfer errors
“It must also become a standard for employees in small and medium-sized enterprises (SMEs). To achieve this, we want to create the framework to ensure occupational pensions become widely available in small enterprises. We will research whether and how possible hurdles can be removed at SMEs.“We will also ensure that the good framework for occupational pensions remains intact within the European framework.”For Karch, the very mention of pensions is a “very encouraging signal”, in which the government “clearly commits to strengthening occupational pensions”.He added that such a paragraph had been absent in any coalition agreement since the contracts on creating the third-pillar Riester pension in 2002.“All the talks I had with political representatives, and my gut feeling, tells me they are taking this really seriously,” he said.“The coalition treaty can also be seen as a confirmation by the government that the occupational sector was right – the pensions system needs reforms.”Following recommendations by the aba, the government is now looking to commission a study on how tax hurdles hinder the spread of occupational pensions among SMEs.Karch stressed the importance of increasing second-pillar pensions across the whole of Germany, not just for SMEs, although he conceded this segment of the economy was “worst off”.He also urged the government to create a more sustainable pension system, with a “dual core” – in other words, carried by the state as well as companies.At the European level, the aba chairman noted “with great concern” a “development contrary to the initial White Paper” on Pensions.In prior versions, he said, the White Paper stressed the importance of social partnerships between the industry and the state.“But now,” he said, “it is simply back to keywords like level playing field, marked-to-market, PRIPs and Solvency II – as if occupational pensions were just products for sale rather than agreements with employer support.” Heribert Karch, chairman at the aba, Germany’s pension fund association, has described the eight-line mention of occupational pensions in the preliminary government coalition agreement as a “step forward” and an “encouraging signal”.After the elections in Germany in mid-September, the conservative CDU and socialist SPD parties agreed on a coalition agreement that is most likely to be the basis for the formation of a two-party government.In the coalition’s 185-page agreement, the term “occupational pensions” is mentioned only in one eight-line paragraph.It reads: “Retirement provision in an age of demographic change becomes more stable when it is based on several strong pillars. We will, therefore, strengthen occupational pensions.
Transmission system operator, 50Hertz, has connected the offshore wind farms Wikinger and Arkona off the island of Rügen to its transmission grid just in time for their commissioning. The Wikinger offshore wind farm is operated by Iberdrola while Arkona is operated by E.ON and Equinor.After three years of construction and a total investment volume of approximately EUR 1.3 billion, renewable energy is now flowing to the Lubmin substation during trial operation. From here it is supplied to the consumers via three 90 kilometers long submarine cables.“We congratulate E.ON and Equinor for the successful commissioning of their first wind farm in the German Baltic Sea and are proud of our cooperation as partners in the construction of the joint Arkona offshore substation”, said 50Hertz CEO, Dr Frank Golletz. “This offshore platform has set a new standard. We will also continue the good European relationship during the operation of the wind farm. We would especially like to thank the Federal Maritime and Hydrographic Agency (BSH) and the State of Mecklenburg-Western Pomerania, who always act as reliable supporters for the offshore projects and their connection. We are also counting on this well-established cooperation for future projects.”The connection of offshore wind farms Wikinger and Arkona, currently the largest investment project of 50Hertz, started in 2015 and is made at the Lubmin substation.For the first time in the Baltic Sea, a grid connection was implemented as a 220 kV three phase current system, enabling a higher power transfer. Until now, the connections of offshore wind farms in the German Baltic Sea consisted of 150 kV three-phase cable systems. At the Lubmin substation, the current is transformed to 380 kilovolts and fed into the 50Hertz transmission system, the company explained.
John R. Fixmer, age 87 of Oldenburg, Indiana, died Sunday, December 25, 2016 at his residence. Born November 19, 1929 in Cincinnati, Ohio, he is the son of Margaret (Nee: DeKors) and John Fixmer. He married Helen Whalen on November 20, 1949 in Poughkeebie, New York and she preceded him in death on January 14, 2001. John was a Navy veteran, having served his country during the Korean War and was a member of the Holy Family Catholic Church in Oldenburg. He was the Head Custodian in the Maintenance Department for the Hamilton County School District, retiring in 1989.John loved the outdoors. Whether it was hunting and fishing or out in the woods splitting firewood. He would often throw on his hip waders, even in the cold weather and head out to go fishing. He enjoyed his fishing trips to Canada with his sons, grandsons, great-grandsons and sons-in-law. John loved to read western novels, he worked on crossword puzzles daily and enjoyed listening to classical music and the music by the Celtic Women. His true passion though was his family. His children, grandchildren and great-grandchildren were truly dear to him and he was very excited about the new arrival of his great-great-grandchild in April.He is survived by his daughters and sons-in-law Dorothy and Craig Lynam of Georgetown, Texas, Karen and Tom Mathes of Columbus, Ohio and Mary Jane and Butch Nunlist of Oldenburg; sons and daughters-in-law John Fixmer of Columbus, Indiana, Robert and Kitty Fixmer of Cincinnati, Ohio and Mark and Sandy Fixmer of Greensburg, Indiana; sisters Betty (Jim) Hines of Cincinnati and Margie (Don) Duke of Bright, Indiana; 17 grandchildren, 34 great-grandchildren and one great-great-grandchild.Visitation is Thursday, December 29th, from 4 – 7 p.m., at the Weigel Funeral Home in Batesville. Funeral services are 10:00 a.m., Friday, December 30th at the Holy Family Church in Oldenburg, with Rev. David Kobak O.F.M. officiating. The burial will follow in the church cemetery, with military graveside rites being conducted by the Batesville V.F.W. Post #3183 and by the Prell-Bland American Legion Post #271. Memorials may be made to the Margaret Mary Health Foundation’s Cancer Care Fund. https://www.mmhealth.org/donate.html. Online condolences may be made at www.weigelfh.com.
Leah Wroten got out in front quickly in the IMCA Sunoco Hobby Stock main but Eric Stanton had the lead at lap four. Stanton, who started sixth, never looked back from there on as he motored to the checkers. Wroten was second. MARSHALLTOWN, Iowa (July 11) – Jeff Aikey put on quite the show at Marshalltown Speedway’s Dale DeFrance/Bill Davis Sr. Memorial, winning IMCA Modified and IMCA Late Model features to bring the curtain down on the Thursday show. Stock Cars – 1. Todd Reitzler; 2. Damon Murty; 3. Steve Meyer; 4. Shawn Ritter; 5. Kyle Everts; 6. David Atcher; 7. Dallon Murty; 8. Jared Daggett; 9. Scott Rice; 10. Patrick Graham; 11. Andrew Burg; 12. Jeff Wollam; 13. David Brandies; 14. Jeff Mueller; 15. Jerry Schipper; 16. Dustin Vis; 17. Jay Schmidt; 18. Donavon Smith; 19. Austin Even; 20. Kenzie Ritter. Harris soon had Richie Gustin to contend with, and after running side-by-side, and a couple of slide jobs, Gustin made it stick and took over the lead. The race was far from over however, as a pair of no. 77 cars came calling. Late Models – 1. Jeff Aikey; 2. Cory Dumpert; 3. Darrel DeFrance; 4. Brian Harris; 5. Jeff Tharp; 6. Andy Nezworski; 7. Ben Seeman; 8. Charlie McKenna; 9. Curtis Glover; 10. Dalton Simonsen; 11. Shawn Cooney; 12. Gary Webb; 13. Jill George; 14. Randy Faux; 15. Todd Johnson; 16. Greg Kastli; 17. Bryce Carey; 18. Kyle Hinrichs; 19. Kyle Krampe; 20. Jenna Johnson Already on the Fast Shafts All-Star ballot, Aikey had taken a liking to the top of the track and sailed to the $1,100 Modified win. Ryan Gustin chased Aikey most of the distance but had to settle for second. Feature Results The finale was 44 laps of Late Model racing, in honor of the late DeFrance’s car number. Fittingly, his son Darrel drew the pole start, then led until Brian Harris nosed under him to take over at lap five. By Joyce Eisele Brayton Carter started in the second row, took command immediately and warded off challenges from Jenae Gustin and then Jake McBirnie to take another Karl Kustoms Northern SportMod win at the High Banks. Modifieds – 1. Jeff Aikey; 2. Ryan Gustin; 3. Ethan Dotson; 4. Richie Gustin; 5. Zack Vanderbeek; 6. Ronn Lauritzen; 7. D.J. Shannon; 8. Tim Ward; 9. Josh Gilman; 10. Ethan Braaksma; 11. Kollin Hibdon; 12. Todd Shute; 13. Jared Van Deest; 14. Jacob Murray; 15. Thor Anderson; 16. Tony Cox; 17. Rod Clement; 18. Jimmy Gustin; 19. Sam Wieben; 20. Anthony Hofbauer. Visiting York, Neb. racer, Cory Dumpert moved from 14th starting to run second and Aikey had moved from 19th starting to third. The closing circuits saw Aikey make his move and he took over the top spot. He held on to the checkers and $1,500 payday. Dumpert was second, DeFrance took third, fourth went to Harris and Jeff Tharp came from 15th starting to score a top five finish. Todd Reitzler went home $1,000 richer after taking top honors in the IMCA Sunoco Stock Cars. Reitzler drew the pole and kept it out front the entire 18 laps. Damon Murty started 15th and ended second after a terrific late surge. Hobby Stocks – 1. Eric Stanton; 2. Leah Wroten; 3. Kaden Reynolds; 4. Jamie Coady; 5. Zach Hovell; 6. Ben Newhouse; 7. Adam Ayers; 8. Luke Bird; 9. Stoney Leonard; 10. Jeremiah Andrews; 11. William Bonnett; 12. William Klosterman; 13. Ray Fees; 14. Butch Lester; 15. Scott Ellis; 16. Mitchell Thomas; 17. Colton Wersinger; 18. Andy Peck; 19. Dan Brady. Northern SportMods – 1. Brayton Carter; 2. Jake McBirnie; 3. Jenae Gustin; 4. Travis Peterson; 5. Cam Reimers; 6. Cory Van Zante; 7. Johnathon Logue; 8. Austin Schrage; 9. Kyle Olson; 10. Josh Sink; 11. Tony Olson; 12. Travis Storjohann; 13. Brady Hilmer; 14. Frank Packer; 15. Kyle Bentley; 16. Brian Lepa; 17. Jason Pansegrau; 18. Ronnie Hults; 19. Michael Parcel; 20. Bill Wears; 21. Curt Hilmer; 22. Andrew Sneller; 23. Bill Hildreth.
Vevay, IN—Switzerland County Sheriff Brian Morton is informing residents that, according to INDOT, the State Road 56 road closure at Lamb that was scheduled to close on this coming Monday has changed. INDOT states that the State Road 56 bridge near Lamb is scheduled to close next week on Wednesday and is expected to reopen by August 21.
Press Association But he also conceded Racing Metro star Sexton will be the front-runner to start against Australia in round two of the autumn internationals. Schmidt explained: “Obviously the coaches will get together and will make a decision. “One great thing about Jonny is he’s well known to me, he’s well known to (assistant coach) Les (Kiss), and Plum (forwards coach John Plumtree) doesn’t care because he’s not a forward! “We would have to strongly consider Jonny coming back in. He does bring that experience and that quality that we know he has. “He wasn’t the starting Lions out-half for no reason. But I’d have to take my hat off to Paddy Jackson. “I think that he’s had to do it pretty tough at times, being thrown in as a very young man and having to direct some very impressive men around the park. “I think he said during the week about telling Paul O’Connell where he needs to be and feeling a little bit intimidated himself. I feel the same intimidation.” If Sexton is the clear first-choice fly-half, Schmidt admitted the battle for the understudy role remains fierce. Jonathan Sexton will be hard to ignore for Ireland’s Australia clash, admits head coach Joe Schmidt. Ulster’s frontline 10 Jackson led the Ireland line with assurance while Ian Madigan might have got the nod for the North American summer tour, but has had to bide his time for chances behind New Zealander Jimmy Gopperth at Leinster this term. Schmidt admitted provincial opportunities certainly sway the thinking at national level. He continued: “I just feel that Ian Madigan hasn’t had too many opportunities this year, but he came on and you immediately saw a little bit of spark. “He wasn’t at 10 but his versatility allowed us to rest Drico (Brian O’Driscoll) a bit and get him on there. “I think at 10 we are building a little bit of depth and I hope that continues to grow and part of that growth is having a competitive environment. “I’m not great at projecting things, but I know next week that we’re probably in a better place than if Jonny played this week and we needed to replace him through injury. “Every game is a final for me at the moment, and of course you always put your best team out in a final, every time. “At the same time you’re trying to grow a group, so I’m relying on the provincial coaches to continue to give opportunities to guys at Pro12 and then particularly at Heineken level.” Ireland’s autumn series is building towards a showdown with New Zealand. But Schmidt admitted he cannot let himself look too closely at the All Blacks’ impressive 26-19 victory over France – not with Australia descending on Dublin next. He added: “Australia are the third-ranked team in the world; we’re a fair way off that. “I can honestly say New Zealand are not really in our mind. “I know who they are. I know they are coming on November 24. “It’s tempting I admit to start looking at them, but we’ve got to be Australia-focused.” The British and Irish Lions fly-half sat out Saturday’s 40-9 Samoa victory with a hip problem, but is expected to be ready for this coming weekend’s visit from the Wallabies. New boss Schmidt was boosted by Ulster outside-half Paddy Jackson’s confident turn at the helm as Ireland racked up five tries at the Aviva Stadium.
ASSISTANT Manager of the Guyana National Stadium at Providence, Mahinder Ghanshiam, has confirmed that the venue is fully prepared and ready to host its leg of the series between the West Indies and India.The two teams clash in the last of three T20 Internationals, starting at 10:30hrs on August 6, then two days later, they meet in the first of three ODI matches, commencing at 09:30hrs – the first time in three decades the two sides will contest an ODI in the South American nation.“We are fully ready and prepared right now … we are putting the finishing touches to what we do best. So, as we speak, most of the systems are in place and we are fully ready to host these matches,” Ghanshiam said.When Chronicle Sport visited the venue yesterday, the place was a hive of activity with workers putting the finishing touches to the various areas of the stadium.Equipped with the best drainage system among the International venues in the West Indies, the outfield looked lush green and billiard-table smooth, despite the prolonged rainy season. To this end, ground staff are confident that once there is no continuous rain on match days, the games will not be affected in any way.Meanwhile, an official from the Guyana Cricket Board (GCB) has confirmed that ticket sales are moving at a fast rate.Tickets for children aged 12 and under are free with the purchase of an adult ticket for all matches. Senior citizens – aged 60 plus – on presentation of a form of national photo identification at local box offices are also eligible for free tickets while stocks last for all matches, except the two MyTeam11 Twenty20 Internationals in the United States.The India cricket team will return to Guyana for the first time since 2002 and will make a maiden appearance at the national stadium, Providence.The One-Day International will be the third between the two sides here. Prior to the ODI on August 8, India have only played ODI cricket here twice, in 1983, when they beat the West Indies by 25 runs at Albion and at Bourda in 1989 when West Indies won by 101 runs.The Windies and India will also play two Tests from August 22 to 26 at the Vivian Richards Cricket Ground in Antigua and from August 30 to September 3 at Sabina Park in Jamaica – during the five-week tour.The India cricket team toured the Caribbean in June and July 2017 to play five One-Day Internationals (ODIs) and a Twenty20 International (T20I) match. India won the ODI series 3-1. The West Indies won the one-off T20I match by nine wickets.